From harriske at uw.edu Tue Sep 13 14:52:27 2022 From: harriske at uw.edu (Kelley Harris) Date: Wed Mar 20 12:11:54 2024 Subject: [PopGenLunch] David Balding seminar on September 28th Message-ID: Hi Seattle popgen enthusiasts, On Wednesday September 28th, we're going to have a special visit from Professor David Balding of the University of Melbourne! He'll be giving a seminar in the Hans Rowling Building on 15th Avenue in room HRC 370 at 12:30 PM. UW people who need Husky card access to the HRC building should email their name (First and Last) and UWnetid to sjcoke@uw.edu by Monday Sept 26. The talk title and abstract are as follows: *Title*: "Genome-wide genetic models for association, heritability analyses and prediction? *Abstract*: Although simultaneous analysis of genome-wide SNPs has been popular for over a decade, the problems posed by more SNPs than study participants (more parameters than data points), and correlations among the SNPs (linkage disequilibrium, LD), have not been adequately overcome so that almost all published genome-wide analyses are suboptimal in ways that are easily improved. While there has been much attention paid to the shape of prior distributions for SNP effect sizes, we argue that this attention is misplaced. We focus on what we call the "heritability model": a low-dimensional, deterministic model for the expected heritability at each SNP, for both individual-data and summary-statistic analyses. The 1-df uniform heritability model has been implicitly adopted in a wide range of analyses, but even within the class of 1-df models there are much better choices. Further, there are many other predictors of heritability based on allele frequency, LD and functional annotations leading to substantial improvements in estimates of heritability and selection parameters over traits, and over genome regions, as well as improvements in gene-based association testing and prediction. Key collaborators Doug Speed, Aarhus, Denmark and Melbourne PhD student Anubhav Kaphle. A few slots to meet with Prof. Balding are still available--if you're interested in one, please email Bruce Weir at bsweir@uw.edu. Hope you've had a great summer, Kelley -- <><><><><> Kelley Harris (She/her) Assistant Professor of Genome Sciences University of Washington -------------- next part -------------- An HTML attachment was scrubbed... URL: From bsweir at uw.edu Wed Sep 14 17:28:58 2022 From: bsweir at uw.edu (Bruce S Weir) Date: Wed Mar 20 12:11:54 2024 Subject: [PopGenLunch] David Balding seminar on September 28th In-Reply-To: References: Message-ID: Hello all David?s talk will be hyrid, but you are encouraged to come in person and see our new digs. HRC 370 (one block from Foege: the large new white building on 15th Avenue). If you haven?t beeb up to the 3rd floor previously, please let us know so your Husky card can be authorized. I can escort non-UW folk. The zoom link will be: https://washington.zoom.us/j/2627590159 Best wishes, Bruce From: Kelley Harris Sent: Tuesday, September 13, 2022 2:52 PM To: popgenlunch@u.washington.edu Cc: Bruce S Weir Subject: David Balding seminar on September 28th Hi Seattle popgen enthusiasts, On Wednesday September 28th, we're going to have a special visit from Professor David Balding of the University of Melbourne! He'll be giving a seminar in the Hans Rowling Building on 15th Avenue in room HRC 370 at 12:30 PM. UW people who need Husky card access to the HRC building should email their name (First and Last) and UWnetid to sjcoke@uw.edu by Monday Sept 26. The talk title and abstract are as follows: Title: "Genome-wide genetic models for association, heritability analyses and prediction? Abstract: Although simultaneous analysis of genome-wide SNPs has been popular for over a decade, the problems posed by more SNPs than study participants (more parameters than data points), and correlations among the SNPs (linkage disequilibrium, LD), have not been adequately overcome so that almost all published genome-wide analyses are suboptimal in ways that are easily improved. While there has been much attention paid to the shape of prior distributions for SNP effect sizes, we argue that this attention is misplaced. We focus on what we call the "heritability model": a low-dimensional, deterministic model for the expected heritability at each SNP, for both individual-data and summary-statistic analyses. The 1-df uniform heritability model has been implicitly adopted in a wide range of analyses, but even within the class of 1-df models there are much better choices. Further, there are many other predictors of heritability based on allele frequency, LD and functional annotations leading to substantial improvements in estimates of heritability and selection parameters over traits, and over genome regions, as well as improvements in gene-based association testing and prediction. Key collaborators Doug Speed, Aarhus, Denmark and Melbourne PhD student Anubhav Kaphle. A few slots to meet with Prof. Balding are still available--if you're interested in one, please email Bruce Weir at bsweir@uw.edu. Hope you've had a great summer, Kelley -- <><><><><> Kelley Harris (She/her) Assistant Professor of Genome Sciences University of Washington -------------- next part -------------- An HTML attachment was scrubbed... URL: From em27 at uw.edu Tue Sep 27 09:02:00 2022 From: em27 at uw.edu (Elizabeth Blue) Date: Wed Mar 20 12:11:55 2024 Subject: [PopGenLunch] DRIFT symposium at ASHG Message-ID: Hi everyone, If you are planning to attend ASHG, consider attending this cool symposium on research in founder populations from October 24th-25th at one of the hotels (flyer and agenda attached). Registration is free, see https://cvent.me/q3XK9N *. * All the best, Liz [image: image.png] -- Elizabeth Blue, Ph.D. Associate Professor Division of Medical Genetics Department of Medicine University of Washington HSB H132, BOX 357720 1959 NE Pacific St, Seattle, WA 98195-7720 206.685.4666 em27@uw.edu she/her/hers -------------- next part -------------- An HTML attachment was scrubbed... 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